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9 materials found

Scientific topics: Toxicology  or Database management 


Compartición, análisis y almacenamiento de datos genómicos con RD-Connect GPAP y EGA

El Centro Nacional de Análisis Genómico (CNAG-CRG) y la European Genome-Phenome Archive (EGA) organizan un curso práctico sobre el uso de herramientas para compartir y analizar datos genómicos en el marco del proyecto VEIS - Valorización de EGA para la Industria y la Sociedad. En el primer...

Scientific topics: Data integration and warehousing, Database management, Genomics

Resource type: Video

Compartición, análisis y almacenamiento de datos genómicos con RD-Connect GPAP y EGA http://tess.elixir-uk.org/materials/comparticion-analisis-y-almacenamiento-de-datos-genomicos-con-rd-connect-gpap-y-ega El Centro Nacional de Análisis Genómico (CNAG-CRG) y la European Genome-Phenome Archive (EGA) organizan un curso práctico sobre el uso de herramientas para compartir y analizar datos genómicos en el marco del proyecto VEIS - Valorización de EGA para la Industria y la Sociedad. En el primer módulo del curso se presentará la plataforma RD-Connect GPAP que permite integrar, compartir y analizar datos genómicos y fenotípicos de manera segura entre los equipos clínicos y de investigación autorizados, facilitando el diagnóstico de Enfermedades Raras y la identificación de nuevas asociaciones gen-enfermedad. La interfaz gráfica de la plataforma y sus numerosos recursos conectados permiten analizar e interpretar datos de manera eficaz e intuitiva sin necesidad de tener formación en Bioinformática. La RD-Connect GPAP, coordinada y desarrollada por el CNAG-CRG y reconocida por el International Rare Disease Consortium (IRDiRC), hospeda actualmente datos pseudonimizados de más de 20.000 pacientes y familiares y ha contribuido al diagnóstico de cientos de casos. En el segundo módulo se seguirá la demostración de la plataforma RD-Connect GPAP para el análisis y reanálisis de datos de pacientes con enfermedades raras y se explicará cómo las herramientas ofrecidas por EGA hacen más fácil y segura la compartición y el almacenamiento de los datos. El curso lo impartirán Gemma Bullich y Leslie Matalonga de la Unidad de Bionformática del CNAG-CRG y Teresa d'Altri y Babita Singh de EGA el 17 de diciembre de 10 a 14 h. La agenda del curso es la siguiente: Parte 1. Módulo clínico (RD-Connect GPAP) 1.1 Introducción a la plataforma RD-Connect e importancia del uso de ontologías y estándares (HPO, ORDO, etc) para la integración de datos fenotípicos en el análisis (gen)ómico 1.2 Hands-on: Phenostore: entrada de datos fenotípicos de pacientes con enfermedades raras para el posterior análisis de datos genómicos Parte 2. Módulo genético (EGA y RD-Connect GPAP) 2.1 Secuenciación y análisis de datos genómicos 2.2 European Genome-Phenome Archive y compartición de datos (en inglés) 2.3 Hands-on: Resolución de casos de pacientes con enfermedades raras entrados en parte 1 con RD-Connect GPAP Parte 3. Discusión y preguntas Data integration and warehousing Database management Genomics Clinical Scientists
OpenRiskNet: Ontology Walkthrough and Workshop

Workshop of 1.5h where the eNanoMapper ontology and a few uses are discussed. The exercises walk the audience trough the principles, uses, and demonstrates how they can actively work with the ontology.

Scientific topics: Ontology and terminology, Toxicology

Resource type: Tutorial

OpenRiskNet: Ontology Walkthrough and Workshop http://tess.elixir-uk.org/materials/openrisknet-ontology-walkthrough-and-workshop Workshop of 1.5h where the eNanoMapper ontology and a few uses are discussed. The exercises walk the audience trough the principles, uses, and demonstrates how they can actively work with the ontology. Ontology and terminology Toxicology Biologists bioinformaticians Chemists
A Critical Guide to the neXtProt knowledgebase: querying using SPARQL

This Critical Guide in the Introduction to Bioinformatics series briefly outlines how to explore the neXtProt human protein database using SPARQL. While text indexation has made database contents more accessible, being able to combine search criteria for specific content permits more powerful...

Scientific topics: Database management

Keywords: Human protein database, Introduction bioinformatics, Introduction nextprot, Nextprot data model, Rdf triples, Semantic triples, Sparql queries, Sparql syntax, Training material

A Critical Guide to the neXtProt knowledgebase: querying using SPARQL http://tess.elixir-uk.org/materials/a-critical-guide-to-the-nextprot-knowledgebase-querying-using-sparql This Critical Guide in the Introduction to Bioinformatics series briefly outlines how to explore the neXtProt human protein database using SPARQL. While text indexation has made database contents more accessible, being able to combine search criteria for specific content permits more powerful querying, and provides a means to mine the information stored in databases. This Guide illustrates the use of the SPARQL semantic query language to interrogate neXtProt and other databases that provide SPARQL endpoints. Specifically, the Guide introduces the concept of database ‘semantic triples’, and examines features of the neXtProt data model. On reading this Guide, and completing the exercises, users will be able to: i) identify key entities within the neXtProt data model; ii) explain what these entities represent, what information they contain and what the information is used for; iii) identify key SPARQL syntax elements; iv) understand SPARQL tutorial examples; and v) write a SPARQL query to retrieve entries matching specific criteria. Database management Human protein database, Introduction bioinformatics, Introduction nextprot, Nextprot data model, Rdf triples, Semantic triples, Sparql queries, Sparql syntax, Training material Beginners 2019-06-06
Adding nanomaterial data

This tutorial describes how nanomaterial data can be added to an eNanoMapper server using a RDF format.

Scientific topics: Database management, Toxicology

Keywords: nanotoxicology, enanomapper, resource description framework, ontology

Resource type: Tutorial

Adding nanomaterial data http://tess.elixir-uk.org/materials/adding-nanomaterial-data This tutorial describes how nanomaterial data can be added to an eNanoMapper server using a RDF format. Database management Toxicology nanotoxicology, enanomapper, resource description framework, ontology programmers data entering
A Critical Guide to the PDB

This Critical Guide in the Introduction to Bioinformatics series provides a brief outline of the Protein Data Bank – the PDB – the world’s primary repository of biological macromolecular structures. The rationale for creating the resource and the kinds of information it provides are discussed,...

Scientific topics: Database management

Keywords: Introduction bioinformatics, Introduction pdb, Protein structure analysis, Protein structure databases, Protein structures

A Critical Guide to the PDB http://tess.elixir-uk.org/materials/a-critical-guide-to-the-pdb This Critical Guide in the Introduction to Bioinformatics series provides a brief outline of the Protein Data Bank – the PDB – the world’s primary repository of biological macromolecular structures. The rationale for creating the resource and the kinds of information it provides are discussed, and issues relating to its evolution and growth are explored. Specifically, this Guide introduces the principal features of the PDB, the nature (and quality) of its contents and how these may be interrogated. On reading this Guide, users will be able to: i) explain some of the ways in which knowledge of protein structures is useful; ii) identify the constituent databases of the wwPDB; iii) explain key features of the RCSB PDB in terms of its data distribution, growth and redundancy statistics; iv) search the PDB using simple and advanced keywords and full sequences, and analyse differences between them; and v) explain various structural quality criteria, and infer the quality of individual PDB entries. Database management Introduction bioinformatics, Introduction pdb, Protein structure analysis, Protein structure databases, Protein structures Beginners 2018-09-08
A Critical Guide to InterPro

This Critical Guide in the Introduction to Bioinformatics series provides an introduction to the InterPro database, the largest, most comprehensive, integrated protein family database in the world. The rationale for creating the resource, the nature of its contributing databases and the kinds of...

Scientific topics: Database management

Keywords: Introduction bioinformatics, Introduction interpro, Protein family classification, Protein family databases, Protein family hierarchies, Protein function annotation, Protein sequence analysis

A Critical Guide to InterPro http://tess.elixir-uk.org/materials/a-critical-guide-to-interpro This Critical Guide in the Introduction to Bioinformatics series provides an introduction to the InterPro database, the largest, most comprehensive, integrated protein family database in the world. The rationale for creating the resource, the nature of its contributing databases and the kinds of information they provide are discussed, and the role of InterPro in protein classification and function-annotation projects is outlined. Specifically, this Guide introduces the principal components of the InterPro database, the differences between them, and how their integration creates a resource whose diagnostic power is greater than the sum of its parts. On reading this Guide, users will be able to: i) explain how protein family databases are used to help annotate uncharacterised protein sequences; ii) identify InterPro’s constituent data resources and explain the main methods that underpin them; iii) search InterPro using keywords and full sequences; iv) analyse and interpret search results in terms of protein family hierarchies, their structural domains and functional features; and v) track the provenance of InterPro’s annotations. Database management Introduction bioinformatics, Introduction interpro, Protein family classification, Protein family databases, Protein family hierarchies, Protein function annotation, Protein sequence analysis Beginners 2018-09-08
A Critical Guide to the UniProtKB Flat-file Format

This Critical Guide briefly presents the need for biological databases and for a standard format for storing and organising biological data. Web-based interfaces have made databases more user-friendly, but knowledge of the underlying file format offers a deeper understanding of how to navigate...

Scientific topics: Database management

Keywords: Flat file databases, Flat files, Introduction bioinformatics, Uniprotkb flat file format

A Critical Guide to the UniProtKB Flat-file Format http://tess.elixir-uk.org/materials/a-critical-guide-to-the-uniprotkb-flat-file-format This Critical Guide briefly presents the need for biological databases and for a standard format for storing and organising biological data. Web-based interfaces have made databases more user-friendly, but knowledge of the underlying file format offers a deeper understanding of how to navigate and mine the information they contain, so that humans and machines can get the most out of them. This Guide explores the file format that underpins one of today’s most popular protein sequence databases – UniProtKB. Specifically, this Guide introduces the concept of database ‘flat-files’, and examines features of the UniProtKB flat-file format. On reading this Guide, users will be able to: i) identify key fields within UniProtKB/Swiss-Prot and UniProtKB/TrEMBL flat-files; ii) explain what these fields mean, what information they contain and what the information is used for; iii) analyse the information in different fields and infer structural and functional features of a sequence; iv) examine and investigate the provenance of annotations; and v) compare annotations at different time-points and evaluate the likely impact of annotation changes. Database management Flat file databases, Flat files, Introduction bioinformatics, Uniprotkb flat file format Beginners 2018-09-08
A Critical Guide to UniProtKB

This Critical Guide in the Introduction to Bioinformatics series provides a brief outline of the UniProt protein sequence database, with a particular focus on the UniProt Knowledgebase – UniProtKB. The rationale for creating the resource, its contributing databases and the kinds of information...

Scientific topics: Database management

Keywords: Introduction bioinformatics, Introduction uniprot, Protein sequence databases, Uniprot knowledgebase

A Critical Guide to UniProtKB http://tess.elixir-uk.org/materials/a-critical-guide-to-uniprotkb This Critical Guide in the Introduction to Bioinformatics series provides a brief outline of the UniProt protein sequence database, with a particular focus on the UniProt Knowledgebase – UniProtKB. The rationale for creating the resource, its contributing databases and the kinds of information they provide are discussed, and issues behind the quality of their annotations are explored. Specifically, this Guide introduces the principal components of the UniProt Knowledgebase, and the differences between them. On reading this Guide, users will be able to: i) identify and explain the characteristic features of UniProtKB/Swiss-Prot and UniProtKB/TrEMBL entries; ii) distinguish annotations that are computed, and hence not experimentally validated; iii) search UniProtKB using keywords, full sequences and peptides, and interpret the results; iv) analyse and track the provenance of annotations; and v) infer which annotations are likely to be accurate and which erroneous. Database management Introduction bioinformatics, Introduction uniprot, Protein sequence databases, Uniprot knowledgebase Beginners 2018-09-08
TGAC_SeqAhead: NGS current challenges and data analysis for plant researchers

Hands on course held at TGAC (http://www.tgac.ac.uk/) on Monday 19 to Friday 23 May 2014 What is this workshop about? The course will combine lectures and led discussions to identify key challenges, opportunities and bottlenecks, with practical session on: Automated and standardized data...

Scientific topics: Sequence analysis, Plant biology, Database management, Bioinformatics

Keywords: Ngs, Ngs bioinformatics, Plants bioinformatics

TGAC_SeqAhead: NGS current challenges and data analysis for plant researchers http://tess.elixir-uk.org/materials/tgac_seqahead-ngs-current-challenges-and-data-analysis-for-plant-researchers Hands on course held at TGAC (http://www.tgac.ac.uk/) on Monday 19 to Friday 23 May 2014 What is this workshop about? The course will combine lectures and led discussions to identify key challenges, opportunities and bottlenecks, with practical session on: Automated and standardized data analysis for plant species data Data quality checks Estimation of reproducibility Batch effects Statistical concepts Importance of standards Data formats Data integration What will I learn? To discuss and reflect on best practice of experimental design and control for using NGS technologies in their context of addressing biological questions Identify key challenges, opportunities and bottlenecks Offering a platform for discussion and exploration of the challenges in plant research with a particular emphasis for agri-bioinformatics Sequence analysis Plant biology Database management Bioinformatics Ngs, Ngs bioinformatics, Plants bioinformatics PhD students plant researchers post-docs 2015-06-22 2017-10-09